Polysaccharide isolated from Korean-style soy sauce activates macrophages via the MAPK and NK-?B pathways

Soy sauce is a staple fermented food in Korea, however, there are relatively limited studies on soy Korea compared to that Japan. In this study, the immuno-stimulating activities polysaccharides isolated from and Crude was isolated, which were named as Korean-style (KSS-0) Japanese-style (JSS-0). Then, difference cytokine production peritoneal macrophages, KSS-0 showed higher than JSS-0. The purified into two polysaccharides, KSS-I KSS-II. consisted mainly galacturonic acid, xylose, galactose. Out of four KSS-II enhanced NO cytokines most. Western blot analysis phosphorylated MAPKs nuclear factor NF-?B RAW 264.7 cells dose-dependent manner. These results suggested activates macrophages via MAPK pathways, also induces an increase production. conclusion, Korean have better immune-stimulating those Japan may be used potential functional foods.